Mechanisms of Actions of Inhaled Anesthetics

“Suffering so great as I underwent cannot be expressed in words . . . but the blank whirlwind of emotion, the horror of great darkness, and the sense of desertion by God and man, which swept through my mind, and overwhelmed my heart, I can never forget.” 1 Such was the experience of surgery before O...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 348; no. 21; pp. 2110 - 2124
Main Authors Campagna, Jason A, Miller, Keith W, Forman, Stuart A
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 22.05.2003
Subjects
Anesthesia
Anesthesia, General - adverse effects
Anesthetics, Inhalation - classification
Anesthetics, Inhalation - pharmacology
Animals
Binding sites
Central Nervous System - drug effects
Genetic Testing
Humans
Ion Channels - drug effects
Mice
Mice, Knockout
Mortality
Mutation
Neural networks
Patient satisfaction
Pharmacogenetics
Receptors, GABA-A - drug effects
Synapses - drug effects
Synapses - physiology
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Summary:“Suffering so great as I underwent cannot be expressed in words . . . but the blank whirlwind of emotion, the horror of great darkness, and the sense of desertion by God and man, which swept through my mind, and overwhelmed my heart, I can never forget.” 1 Such was the experience of surgery before October 1846, when William Morton's successful public demonstration of ether anesthesia at Massachusetts General Hospital led to its widespread acceptance by surgeons. Today, anesthesiologists employ a wide variety of drugs, some of which they use exclusively to produce general anesthesia. 2 , 3 This review focuses on the . . .
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMra021261