Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain

• Published in: Brain research. Developmental brain research Vol. 157; no. 1; pp. 98 - 102
• Main Authors: Mikati, Mohamad A., Zeinieh, Michele P., Kurdi, Rana M., Harb, Samer A., El Hokayem, Jimmy A., Daderian, Rita H., Shamseddine, Alhan, Obeid, Makram, Bitar, Fadi F., El Sabban, Marwan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 09.06.2005
• Subjects: Acute; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal - physiology; Cell Count - methods; Cell Death - physiology; Chronic; Chronic Disease; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Erythropoietin - blood; Exploratory Behavior - physiology; Hippocampus - growth & development; Hippocampus - pathology; Hippocampus - physiopathology; Hypoxia; Hypoxia - blood; Hypoxia - pathology; Hypoxia - physiopathology; In Situ Nick-End Labeling - methods; Maze Learning - physiology; Rats; Rats, Sprague-Dawley; Time; Time Factors; Hypoxia; Chronic; Development and regeneration; Erythropoietin; Acute
• ISSN: 0165-3806
• DOI: 10.1016/j.devbrainres.2005.03.007

Ten-day-old rat pups (P10) subjected to acute hypoxia (down to 4% O 2) had as adults increased aggression (handling test), memory impairment (water maze test), and decreased CA1 cell counts. Pups subjected to chronic hypoxia (10% O 2 from P0 to P21) had increased aggression, hyperactivity (open-field test), and decreased CA1 cell counts. Chronic hypoxia with superimposed acute hypoxia resulted in consequences that were not different from those of chronic hypoxia.