ACTG2 Variants in Pediatric Chronic Intestinal Pseudo-obstruction With Megacystis

• Published in: Journal of neurogastroenterology and motility Vol. 28; no. 1; pp. 104 - 110
• Main Authors: Hahn, Jong Woo, Moon, Soo Young, Kim, Min Soo, Woo, Min Hyung, Sohn, Min Ji, Kim, Hyun-Young, Seong, Moon-Woo, Park, Sung Sup, Park, Sung-Hye, Moon, Jin Soo, Ko, Jae Sung
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Neurogastroenterology and Motility 30.01.2022; 대한소화기 기능성질환∙운동학회
• Subjects: Original; 내과학; Megacystis; Visceral myopathy; Intestinal pseudo-obstruction
• ISSN: 2093-0879; 2093-0887
• DOI: 10.5056/jnm20243

Chronic intestinal pseudo-obstruction (CIPO) is a clinically heterogeneous syndrome characterized by compromised peristalsis and intestinal obstruction. Variants of actin gamma 2 ( ), a protein crucial for correct enteric muscle contraction, have been found in CIPO patients. The aim of this study is to examine the clinical features and variants in Korean patients with CIPO. From January 1995 to August 2020, 12 patients diagnosed with CIPO were included and genetic analysis testing of was performed. Heterozygous missense variants were found in 6 patients (50.0%). The p.Arg257Cys variant was found in 3 patients, and p.Arg63Gln and p.Arg178His variants were found in 1 patient each. A novel variant, p.Ile193Phe, was found in 1 patient. Three patients were diagnosed at birth, 2 at the age of 1 year, and 1 at 3 years of age. Abnormal prenatal genitourinary ultrasonographic findings were found in all 6 patients; microcolon was found in 4 patients (66.7%), and megacystis in all 6 patients. The pathology showed abnormal ganglion cells as well as myopathic findings. All patients are dependent on total parenteral nutrition and are to date alive. variants are commonly found in Korean patients with CIPO. In CIPO patients with megacystis and abnormal prenatal ultrasonography, genetic testing of should be considered. Molecular diagnosis of CIPO is more important than pathologic diagnosis.