Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

• Published in: Chemical communications (Cambridge, England) Vol. 53; no. 95; pp. 12822 - 12825
• Main Authors: Sedgwick, Adam C, Han, Hai-Hao, Gardiner, Jordan E, Bull, Steven D, He, Xiao-Peng, James, Tony D
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 28.11.2017; Royal Society of Chemistry
• Subjects: aqueous solutions; chemical compounds; chemical reactions; Chemistry; Chemistry, Multidisciplinary; fluorescence; fluorescent dyes; Fluorescent indicators; image analysis; Mitochondria; Physical Sciences; Science & Technology; solubility; DUAL-CHANNEL PROBE; OXIDATIVE STRESS; SUPEROXIDE; FAR-RED; CHROMOPHORES; IN-VIVO; NITRIC-OXIDE; HYDROGEN-PEROXIDE; LIVING CELLS; NITRATION

Two boronate fluorescent probes have been developed for the detection of peroxynitrite ( TCFB1 and TCFB2 ). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria...