Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

Two boronate fluorescent probes have been developed for the detection of peroxynitrite ( TCFB1 and TCFB2 ). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria...

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Published inChemical communications (Cambridge, England) Vol. 53; no. 95; pp. 12822 - 12825
Main Authors Sedgwick, Adam C, Han, Hai-Hao, Gardiner, Jordan E, Bull, Steven D, He, Xiao-Peng, James, Tony D
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 28.11.2017
Royal Society of Chemistry
Subjects
aqueous solutions
chemical compounds
chemical reactions
Chemistry
Chemistry, Multidisciplinary
fluorescence
fluorescent dyes
Fluorescent indicators
image analysis
Mitochondria
Physical Sciences
Science & Technology
solubility
DUAL-CHANNEL PROBE
OXIDATIVE STRESS
SUPEROXIDE
FAR-RED
CHROMOPHORES
IN-VIVO
NITRIC-OXIDE
HYDROGEN-PEROXIDE
LIVING CELLS
NITRATION
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Summary:Two boronate fluorescent probes have been developed for the detection of peroxynitrite ( TCFB1 and TCFB2 ). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459). Two boronate fluorescent probes have been developed for the detection of peroxynitrite ( TCFB1 and TCFB2 ).
Bibliography:10.1039/c7cc07845e
Electronic supplementary information (ESI) available. See DOI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c7cc07845e