The Oral Glucose Tolerance Test—Is It Time for a Change?—A Literature Review with an Emphasis on Pregnancy

Globally, gestational diabetes (GDM) is increasing at an alarming rate. This increase is linked to the rise in obesity rates among women of reproductive age. GDM poses a major global health problem due to the related micro- and macro-vascular complications of subsequent Type 2 diabetes and the impac...

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Published inJournal of clinical medicine Vol. 9; no. 11; p. 3451
Main Authors Bogdanet, Delia, O’Shea, Paula, Lyons, Claire, Shafat, Amir, Dunne, Fidelma
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.10.2020
MDPI
Subjects
Biomarkers
Clinical medicine
Fasting
Gestational age
Gestational diabetes
Glucose
Pregnancy
Reproducibility
Review
Risk factors
Womens health
oral glucose tolerance test
diabetes
gestational diabetes
reproducibility
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Summary:Globally, gestational diabetes (GDM) is increasing at an alarming rate. This increase is linked to the rise in obesity rates among women of reproductive age. GDM poses a major global health problem due to the related micro- and macro-vascular complications of subsequent Type 2 diabetes and the impact on the future health of generations through the long-term impact of GDM on both mothers and their infants. Therefore, correctly identifying subjects as having GDM is of utmost importance. The oral glucose tolerance test (OGTT) has been the mainstay for diagnosing gestational diabetes for decades. However, this test is deeply flawed. In this review, we explore a history of the OGTT, its reproducibility and the many factors that can impact its results with an emphasis on pregnancy.
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9113451