Spermatogenic patterns and early Embryo development after intracytoplasmic sperm injection in severe oligoasthenozoospermia

• Published in: Journal of assisted reproduction and genetics Vol. 20; no. 3; pp. 106 - 112
• Main Authors: VENDRELL, José M, ARAN, Begona, VEIGA, Anna, GARCIA, Ferran, COROLEU, Buenaventura, EGOZCUE, Susana, EGOZCUE, Josep, BARRI, Pere N
• Format: Journal Article
• Language: English
• Published: New York, NY Kluwer/Plenum 01.03.2003; Springer Nature B.V; Kluwer Academic Publishers-Plenum Publishers
• Subjects: Biological and medical sciences; Biopsy; Early stages. Segmentation. Gastrulation. Neurulation; Embryo, Mammalian; Embryology: invertebrates and vertebrates. Teratology; Embryos; Female; Fundamental and applied biological sciences. Psychology; Humans; Male; Motility; Oligospermia - therapy; Ovaries; Pregnancy; Pregnancy Outcome; Regression analysis; Sperm; Sperm Injections, Intracytoplasmic; Spermatogenesis; Ultrasonic imaging; Vagina; Variables; Variance analysis; Spain; Chromosomal aberration; Human; Embryonic development; Embryo; Spermatozoa; Early embryo developments; Intracytoplasmic sperm injection; oligoasthenozoospermia; Chromosome; Meiosis; Germinal cell; Semen disorders; meiotic chromosome anomalies; Cell density; Oligospermia; sperm concentration; Female; Male sterility; Asthenospermia; Male genital diseases
• ISSN: 1058-0468; 1573-7330
• DOI: 10.1023/A:1022626823328

Evaluate the influence of different baseline spermatogenic patterns [meiotic pattern (normal or abnormal), sperm concentration (> 1 x 10(6)/mL or < or = 1 x 10(6)/mL), and the combined meiosis-sperm concentration pattern] on early embryo development in severe oligoasthenozoospermia. Embryo outcomes (fertilization rate, cleavage rate, and 4-cell stage embryo division rate on day 2) after IVF-ICSI in 75 oligoasthenozoospermia and 79 normozoospermic males. The embryo division rate was significantly lower in oligoasthenozoospermia compared to normozoospermia (50.43% vs. 58.72%, p < 0.01) and in the oligoasthenozoospermia group for meiotic anomalies (43.40%), sperm concentration < or = 1 x 10(6)/mL (44.35%), and the combined pattern < or = 1 x 10(6)/mL with meiotic anomalies (37.17%). Logistic regression analysis showed a synergic effect (OR = 2.00; 95% CI = 1.28-3.12) when the two spermatogenic patterns predictive of slow embryo development [meiotic anomalies (OR = 1.49; 95% CI = 1.03-2.15) and sperm concentration < or = 1 x 10(6)/mL (OR = 1.53; 95% CI = 1.09-2.13)] were present. The data suggest that the early embryonic developmental capacity is inversely related to the severity of spermatogenic impairment (meiotic anomalies and/or sperm concentration < or = 1 x 10(6)/mL).