Association between apolipoprotein E polymorphism and coronary artery disease in the Kermanshah population in Iran

• Published in: Clinical biochemistry Vol. 39; no. 6; pp. 613 - 616
• Main Authors: Kharrazi, H., Vaisi Raygani, A., Sabokroh, A.R., Pourmotabbed, T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2006
• Subjects: APOE; Apolipoproteins E - genetics; Base Sequence; Coronary artery disease; Coronary Artery Disease - epidemiology; Coronary Artery Disease - genetics; DNA Primers; Female; Genetic polymorphism; Genetic risk factor; Genetics, Population; Humans; Iran; Iran - epidemiology; Kermanshah; Lipid profile; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Variants; Iran; Variants; Genetic risk factor; Iran; Kermanshah; Genetic polymorphism; Lipid profile; APOE; Coronary artery disease
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/j.clinbiochem.2006.02.002

Coronary artery disease (CAD) is the major cause of death in developing countries, such as Iran. The apolipoprotein E gene (APOE) is considered an important genetic determinant of CAD. In this study, the relationship between APOE polymorphism with lipid variation in CAD patients in Kermanshah, Iran was investigated. This case–control study consisted of 115 CAD patients who angiographically had at least 30% stenosis and 135 unrelated controls. APOE polymorphism was detected by PCR-RFLP and serum lipid level was measured enzymatically. The APOE-ε4 and -ε2 allele frequencies were significantly higher in the CAD patients than in the control group ( P < 0.001). The CAD patients with ε3/ε4 genotype had also higher TC ( P < 0.001) and LDL-C ( P < 0.01) and lower HDL-C ( P < 0.03) levels than that of the control group. APOE-ε4 allele is a risk factor for CAD, so that carriers of this allele with high levels of LDL-C may be susceptible to CAD and myocardial infarction.