Biotinylated photoactive Pt() anticancer complexes

• Published in: Chemical communications (Cambridge, England) Vol. 56; no. 15; pp. 232 - 2323
• Main Authors: Shi, Huayun, Imberti, Cinzia, Huang, Huaiyi, Hands-Portman, Ian, Sadler, Peter J
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 21.02.2020
• Subjects: animal ovaries; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; avidin; Biotin; Biotinylation; Cell Line, Tumor; Cell Proliferation - drug effects; chemical compounds; chemical reactions; Decomposition reactions; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; human diseases; Humans; irradiation; light; Molecular Structure; neoplasm cells; NMR; Nuclear magnetic resonance; Optical Imaging; Organoplatinum Compounds - chemical synthesis; Organoplatinum Compounds - chemistry; Organoplatinum Compounds - pharmacology; ovarian neoplasms; Ovarian Neoplasms - diagnostic imaging; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - pathology; Photochemical Processes; Photodecomposition; Structure-Activity Relationship; Titration

Novel biotinylated diazido-Pt( iv ) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all- trans -[Pt(py) 2 (N 3 ) 2 (biotin)(OH)] ( 2a ) were enhanced significantly when bound to avidin; irradiation induced dramatic...