Biotinylated photoactive Pt() anticancer complexes

Novel biotinylated diazido-Pt( iv ) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all- trans -[Pt(py) 2 (N 3 ) 2 (biotin)(OH)] ( 2a ) were enhanced significantly when bound to avidin; irradiation induced dramatic...

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Published inChemical communications (Cambridge, England) Vol. 56; no. 15; pp. 232 - 2323
Main Authors Shi, Huayun, Imberti, Cinzia, Huang, Huaiyi, Hands-Portman, Ian, Sadler, Peter J
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 21.02.2020
Subjects
animal ovaries
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
avidin
Biotin
Biotinylation
Cell Line, Tumor
Cell Proliferation - drug effects
chemical compounds
chemical reactions
Decomposition reactions
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Female
human diseases
Humans
irradiation
light
Molecular Structure
neoplasm cells
NMR
Nuclear magnetic resonance
Optical Imaging
Organoplatinum Compounds - chemical synthesis
Organoplatinum Compounds - chemistry
Organoplatinum Compounds - pharmacology
ovarian neoplasms
Ovarian Neoplasms - diagnostic imaging
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - pathology
Photochemical Processes
Photodecomposition
Structure-Activity Relationship
Titration
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Summary:Novel biotinylated diazido-Pt( iv ) complexes exhibit high visible light photocytotoxicity while being stable in the dark. Photocytotoxicity and cellular accumulation of all- trans -[Pt(py) 2 (N 3 ) 2 (biotin)(OH)] ( 2a ) were enhanced significantly when bound to avidin; irradiation induced dramatic cellular morphological changes in human ovarian cancer cells treated with 2a . Novel biotinylated diazido-Pt( iv ) complexes exhibit high visible light photocytotoxicity while being stable in the dark.
Bibliography:10.1039/c9cc07845b
Electronic supplementary information (ESI) available: NMR spectra, photodecomposition, UV-vis titration, and experimental details. See DOI
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SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c9cc07845b