Effect of oregano essential oil on the engraftment and development of Lewis carcinoma in F1 DBA C57 black hybrid mice

• Published in: Applied biochemistry and microbiology Vol. 49; no. 4; pp. 432 - 436
• Main Authors: Misharina, T. A, Burlakova, E. B, Fatkullina, L. D, Alinkina, E. S, Vorob’eva, A. K, Medvedeva, I. B, Erokhin, V. N, Semenov, V. A, Nagler, L. G, Kozachenko, A. I
• Format: Journal Article
• Language: English
• Published: Boston Springer-Verlag 01.07.2013; Springer US; Springer Nature B.V
• Subjects: anticarcinogenic activity; antioxidant activity; Antioxidants; Biochemistry; Biomedical and Life Sciences; brain; carcinoma; Drinking water; enzymes; Essential oils; Hybridization; hybrids; Life Sciences; lipid peroxidation; liver; Medical Microbiology; mice; Microbiology; Oils & fats; oregano; Origanum vulgare; Oxidative stress; Peroxidation; Rodents; Spices; thiobarbituric acid; Lipid Peroxidation Process; Carvacrol; Erythrocyte Haemolysis; Erythrocyte Membrane; Apply Biochemistry
• ISSN: 0003-6838; 1608-3024
• DOI: 10.1134/S0003683813040091

The effect of a low uptake dose of oregano essential oil with drinking water for three months (Origanum vulgare L.) on the degree of Lewis carcinoma engraftment and some parameters of oxidative stress has been studied in vivo using F1 DBA C57 Black hybrid mice. Oregano essential oil has been established to possess an anticancer activity. The degree of tumor engraftment decreased by 1.8 times, its size decreased by 1.5 times, and the development of tumor was significantly suppressed in sick mice under the effect of oregano essential oil. It was found that the uptake of essential oil did not affect the intensity of lipid peroxidation in the brain of mice and resulted in a significantly (by 36%) decreased content of secondary lipid oxidation products in the liver as shown in a reaction with thiobarbituric acid as compared to control subjects. The activity of antioxidant enzymes was found to increase after three months of essential oil uptake (by 1.5–3 times) as compared to the control group. This effect of essential oil supports the presence of bioantioxidant properties in this essential oil.