Effects of MgF2 coating on the biodegradation and biological properties of magnesium

• Published in: Surface & coatings technology Vol. 422; p. 127552
• Main Authors: Lou, Jie, Sun, Yu, Chen, Yudie, Zan, Rui, Peng, Hongzhou, Yang, Shi, Kang, Xinbao, Peng, Zhaoxiang, Wang, Wenhui, Zhang, Xiaonong
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier B.V 25.09.2021; Elsevier BV
• Subjects: Biocompatibility; Biodegradability; Biodegradable Mg; Biodegradation; Biological properties; Biomedical materials; Coating effects; Corrosion resistance; Immersion tests (corrosion); Magnesium fluorides; MgF2 film; Orthopedics; Process parameters; Thickness; Toxicity testing; Corrosion resistance; MgF2 film; Biocompatibility; Biodegradable Mg
• ISSN: 0257-8972; 1879-3347
• DOI: 10.1016/j.surfcoat.2021.127552

The rapid degradation rate has been a hindrance to promote the clinical application of biodegradable magnesium (Mg). To solve this problem, researchers have devoted to the surface modification of Mg for years. Magnesium fluoride (MgF2) coating is easy to obtain and has excellent corrosion resistance, which has long-term research value in surface modification of magnesium implants. However, we are still lacking in understanding the influence of process parameters, sizes of film and other factors on the protective effect of MgF2 coating, and its biocompatibility also needs to be verified. In this paper, the sizes, corrosion resistance and biocompatibility of the chemical conversion film (MgF2) with different preparation time were studied. Through in vitro immersion, electrochemical simulation, structure and composition analysis and cytotoxicity test, we derived the rules that the MgF2 film with greater thickness and better corrosion resistance was prepared under longer preparation time. The differences of several characterization methods were compared. Meanwhile, we demonstrated that the MgF2 film had great cytocompatibility and the attachment and growth of osteoblasts on the surface of the film were quite satisfied. These conclusions are of great significance for the applications of the MgF2 film in orthopedic clinical implantation. [Display omitted] •The thickness of MgF2 coating increases with the prolongation of preparation time.•The corrosion resistance of MgF2 coating increases with the prolongation of preparation time.•The pH test of immersion shows a deviation from other methods due to the degradation products.•MgF2 coating possesses great cytocompatibility and feasibility for clinical application.