Atlantic salmon ( Salmo salar L.) parr fed genetically modified soybeans and maize: Histological, digestive, metabolic, and immunological investigations

• Published in: Research in veterinary science Vol. 84; no. 3; pp. 395 - 408
• Main Authors: Bakke-McKellep, A.M., Sanden, M., Danieli, A., Acierno, R., Hemre, G.-I., Maffia, M., Krogdahl, Å.
• Format: Journal Article
• Language: English
• Published: England Elsevier India Pvt Ltd 01.06.2008; Elsevier Limited
• Subjects: Animal Feed; Animals; Aquaculture; corn; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Digestion - physiology; digestive enzymes; enzyme activity; Enzymes; experimental diets; feed formulation; Fish; fish feeding; Food, Genetically Modified; genetically modified feeds; Glycine max - genetics; histopathology; Immune System - drug effects; Immunoglobulin M - blood; Immunoglobulin M - drug effects; immunologic techniques; Intestine; juveniles; metabolic studies; Nutrition; Proteins; Salmo salar; Salmo salar - growth & development; Salmo salar - immunology; Salmon; Soybeans; transgenic plants; Transport; Veterinary medicine; Zea mays - genetics; Enzymes; Nutrition; Transport; Intestine; GM; Aquaculture
• ISSN: 0034-5288; 1532-2661
• DOI: 10.1016/j.rvsc.2007.06.008

Physiological and health related responses to dietary inclusion of genetically modified (GM) full-fat soybean meal (Roundup Ready ®; GM-soy) and maize (MON810 ® Bt-maize; GM-maize), as well as non-parental, untransformed lines (nGM-soy and nGM-maize D2), were evaluated in farmed Atlantic salmon ( Salmo salar L.) parr during the first 8 months of feeding. Significant effects of dietary GM presence were only found in intestinal Na +-dependent d-glucose uptake and SGLT1 protein level in the region pyloric caeca in which the highest values were found in the GM-soy, intermediate in the nGM-soy, and lowest in the standard FM fed groups. Data from this study confirm that GM soybeans (RRS ®) and maize (MON810 ®) at inclusion levels of about 6% appear to be as safe as commercially available nGM soy and maize in diets for Atlantic salmon parr. Results from studies with higher inclusion levels and with non-modified, isogenic or near-isogenic parental lines as control groups are pending.