A cross-sectional study of the association between heat shock protein 27 antibody titers, pro-oxidant–antioxidant balance and metabolic syndrome in patients with angiographically-defined coronary artery disease

• Published in: Clinical biochemistry Vol. 44; no. 17; pp. 1390 - 1395
• Main Authors: Sahebkar, Amirhossein, Pourghadamyari, Hossein, Moohebati, Mohsen, Parizadeh, Seyed Mohammad Reza, Falsoleiman, Homa, Dehghani, Mashallah, Fazlinezhad, Afsoon, Akhlaghi, Saeed, Tavallaie, Shima, Paydar, Roghayeh, Ghayour-Mobarhan, Majid, Ferns, Gordon A.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.12.2011; Elsevier
• Subjects: Aged; Antibodies; Antioxidants - metabolism; Autoantibodies - blood; Biological and medical sciences; Biomarkers - blood; Case-Control Studies; Coronary Angiography; Coronary artery disease; Coronary Artery Disease - complications; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - immunology; Cross-Sectional Studies; Female; Fundamental and applied biological sciences. Psychology; Heat shock protein 27; HSP27 Heat-Shock Proteins - immunology; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Metabolic diseases; Metabolic Syndrome - blood; Metabolic Syndrome - complications; Metabolic Syndrome - immunology; Metabolic syndrome X; Middle Aged; Miscellaneous; Multivariate Analysis; Other metabolic disorders; Oxidants - blood; Oxidative stress; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports; Antibodies; Oxidative stress; Metabolic syndrome X; Heat shock protein 27; Coronary artery disease; Endocrinopathy; Human; Antibody; Metabolic diseases; Cardiovascular disease; Oxidant; Antioxidant; Metabolic syndrome; Coronary heart disease; Equilibrium; Posture; Association; Cross sectional study; Clinical biology; Heat shock protein
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/j.clinbiochem.2011.09.011

To investigate the association between serum antibody titers to Hsp27 (anti-Hsp27) and pro-oxidant–antioxidant balance (PAB) in patients with angiographically-defined coronary artery disease (CAD) with or without the metabolic syndrome (MS). Subjects ( n = 243) were classified into MS+ ( n = 161) and MS− ( n = 82) subgroups, based on the AHA/NHBLI criteria. Serum anti-Hsp27 titers were found to be significantly higher in the MS+ vs. MS− group. However, no significant difference was observed in serum PAB values. When assessed for individual components of MS, increased serum anti-Hsp27 was found to be higher in subgroups with elevated triglycerides, elevated blood pressure and reduced high-density lipoprotein cholesterol (HDL-C). Subgroups of patients with elevated triglycerides had higher PAB values. HDL-C was the only significant predictor of anti-Hsp27 in the population as a whole. The evidence from this investigation indicates the presence of elevated anti-Hsp27 in patients with concurrent CAD and MS compared to those with CAD alone. ► Anti-Hsp27 titres were elevated in patients with concurrent CAD and metabolic syndrome compared to those with only CAD. ► Serum prooxidant-antioxidant balance was not elevated in the metabolic syndrome group beyond what is caused by CAD. ► Accumulation of MS features in patients with CAD could be associated with increased risk of vascular complications.