Analysis of the effects of Rosa roxburghii Tratt fruit polyphenols on immune function in mice through gut microbiota and metabolomics: An in vivo preclinical trial study

• Published in: Journal of functional foods Vol. 102; p. 105464
• Main Authors: Liu, Yujie, Zhang, Shuo, Tang, Li, Zhang, Ming, Wang, Pengjiao, Sun, Xiaodong, Shang, Leyuan, Wang, Qi, Zhao, Yanni, Meng, Duo, Luo, Peng, Gao, Xiuli
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.03.2023; Elsevier
• Subjects: Gut microbiota; Immunomodulatory; Metabolomics; Polyphenols; Rosa roxburghii; Gut microbiota; Metabolomics; SRBC; IL-4; IL-5; IL-2; PFC; CRBC; TCA; TNF-α; RRT; NC; HC50; Rosa roxburghii; Polyphenols; DTH; SCFAs; RRTP; Immunomodulatory; TLR
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2023.105464

[Display omitted] •Rosa roxburghii tratt polyphenols regulate cellular and non-specific immunity but have no significant effect on humoral immunity.•Rosa roxburghii tratt polyphenols regulate the differentiation balance of T cells.•Rosa roxburghii tratt polyphenols regulate the proportion of short-chain fatty acid producing bacteria,such as Blautia, Bacteroides, Lachnospiraceae_NK4A136_group, Roseburia.•Rosa roxburghii tratt polyphenols may affect T cells and macrophages through metabolites such as choline in plasma. Various plant polyphenols have been recognized by researchers as functional foods to improve the immune system. Our study showd that Rosa roxburghii Tratt fruit polyphenols (RRTP) could regulate the cellular and innate immune functions of mice. In addition, Compared with the normal control group, RRTP could affecting the balance of lymphocyte subsets. Metabolism studies showed that RRTP altered 46 different metabolites, mainly involving amino acid metabolism, carbohydrate metabolism, and lipid metabolism. Moreover, RRTP has a positive regulatory effect on the gut microbiota, the short-chain fatty acids(SCFAs) producing bacterias: Blautia, Bacteroides, Lachnospiraceae_NK4A136_group, Roseburia increased notably. Measurements of SCFAs in the cecum showed significant increases, suggesting that the immunomodulatory effects of RRTP are closely related to SCFAs. In Conclusion, RRTP could regulate the immune system of mice by regulating the balance of metabolites and intestinal microorganisms, RRTP has the potential to be developed as functional ingredients or foods to promote health.