Association between CHRNA3 rs1051730 Genotype and Lung Cancer Risk in Chinese Han Population： A Case-Control Study

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 33; no. 6; pp. 897 - 901
• Main Author: 任精华 金敏 何文山 刘翠微 蒋顺 陈卫红 杨坤禹 伍钢 张涛
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.12.2013; Cancer Center,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China%Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
• Subjects: Adult; Aged; Case-Control Studies; China; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Lung Neoplasms - etiology; Lung Neoplasms - genetics; Male; Medicine; Medicine & Public Health; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Nicotinic - genetics; Smoking; 中国汉族人群; 关联; 单核苷酸多态性; 基因型; 病例; 等位基因; 肺癌; 风险; China; lung cancer; gene polymorphism; susceptibility; rs1051730
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-013-1218-4

Recent population-based genome wide association studies have revealed potential suscepti- bility loci of lung cancer at the region of chromosome 15q25.1 containing nicotinic acetylcholine re- ceptor genes. The loci increasing lung cancer risk has been widely identified in Caucasians, but whether this association also exists in Asians and whether this association is a direct role or mediated via tobacco smoking indirectly has not been fully established. We conducted a case-control study comprising of 210 histologically confirmed lung cancer cases and 200 healthy controls to examine rsl051730 genotyping, a single nucleotide polymorphism receiving much attention recently, and its influence on lung cancer risk as well as nicotine dependence in a Chinese Han population. Our results showed that the heterozy- gous C/T genotype and minor allele T conferred a significant higher risk of lung cancer than the CC homozygotes and allele C （adjusted OR=2.25, 95% CI=1.0~4.89, P=-0.040 and OR=2.18, 95% CI=1.02~4.67, P=0.045 respectively）. However, no association between the smoking habit and the CHRNA3 rs1051730 polymorphism was observed in this study. The results suggested that the rs1051730 polymorphism may modify susceptibility to lung cancer via a smoking-independent manner among Chinese Han population. Additional studies in vitro and in vivo are warranted to further elucidate the impact ofrsl051730 on lung cancer susceptibility.