Synthesis of β-alkoxy- N -protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening

A regioselective, copper-catalyzed, one-pot aminoalkoxylation of styrenes using primary and secondary alcohols and three different iminoiodanes as alkoxy and nitrogen sources respectively, is reported. The β-alkoxy- -protected phenethylamines obtained were used to synthesise β-alkoxy- -benzylpheneth...

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Published inRSC advances Vol. 8; no. 49; pp. 27919 - 27923
Main Authors Saavedra-Olavarría, Jorge, Madrid-Rojas, Matías, Almodovar, Iriux, Hermosilla-Ibáñez, Patricio, Pérez, Edwin G
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 01.01.2018
The Royal Society of Chemistry
Subjects
Alcohols
Chemical synthesis
Chemistry
Copper
Nitrogen
Ring opening
Styrenes
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Summary:A regioselective, copper-catalyzed, one-pot aminoalkoxylation of styrenes using primary and secondary alcohols and three different iminoiodanes as alkoxy and nitrogen sources respectively, is reported. The β-alkoxy- -protected phenethylamines obtained were used to synthesise β-alkoxy- -benzylphenethylamines which are interesting new compounds that could act as possible neuronal ligands.
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ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra03815e