Digital computer simulation of respiratory response to cerebrospinal fluid PCO2 in the cat

The respiratory control system is treated as linear with a transmission delay between ventilation and sensing points (chemoreceptors). To the accepted variables involving body gas stores, ventilatory effects, transmission effects, and steady state pH, P(CO2), P(O2) chemoreceptor response, certain de...

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Bibliographic Details
Published inBiophysical journal Vol. 5; no. 6; pp. 935 - 945
Main Authors Horgan, J D, Lange, R L
Format Journal Article
LanguageEnglish
Published United States 01.11.1965
Subjects
Animals
Blood Gas Analysis
Carbon Dioxide
Cerebrospinal Fluid
Computers
Hydrogen-Ion Concentration
Hyperventilation
In Vitro Techniques
Medulla Oblongata - physiology
Models, Theoretical
Respiration - physiology
Sensory Receptor Cells - physiology
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Summary:The respiratory control system is treated as linear with a transmission delay between ventilation and sensing points (chemoreceptors). To the accepted variables involving body gas stores, ventilatory effects, transmission effects, and steady state pH, P(CO2), P(O2) chemoreceptor response, certain detailed analysis of the central receptors have been added. By construction of a model for medullary CO(2) receptor utilizing expected values of CNS (central nervous system) circulation, CO(2) production, and tissue-buffering effects, results of experimental observation of the effects of alteration of CSF were simulated. The inclusion of CSF effects also allowed simulation of the response to alteration in inspired CO(2), hyperventilation, and the periodic breathing with prolongation of circulation time.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0006-3495
1542-0086
DOI:10.1016/S0006-3495(65)86760-1