Role of advanced oxidation protein products and Thiol ratio in patients with acute coronary syndromes

• Published in: Clinical biochemistry Vol. 44; no. 8; pp. 605 - 611
• Main Authors: Barsotti, Antonio, Fabbi, Patrizia, Fedele, Massimiliano, Garibaldi, Silvano, Balbi, Manrico, Bezante, Gian Paolo, Risso, Domenico, Indiveri, Francesco, Ghigliotti, Giorgio, Brunelli, Claudio
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.06.2011; Elsevier
• Subjects: Acute Coronary Syndrome - blood; Acute coronary syndromes; Aged; Angina, Unstable - blood; AOPP; Biological and medical sciences; Blood Proteins - metabolism; C-Reactive Protein - metabolism; Cardiology. Vascular system; Cholesterol - blood; Cholesterol, HDL - blood; Coronary heart disease; Female; Heart; Humans; Inflammation; Interleukin-1beta - blood; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Myocardial Infarction - blood; Myocarditis. Cardiomyopathies; Oxidative Stress; oxLDL; Reactive Oxygen Species - metabolism; Sulfhydryl Compounds - blood; Thiols; Triglycerides - blood; AOPP; oxLDL; Oxidative stress; Inflammation; Thiols; Acute coronary syndromes; Human; Thiol; Cardiovascular disease; Coronary heart disease; Myocardial disease; Protein; Clinical biology; Advanced stage; Oxidation; Ratio; Acute coronary syndrome
• ISSN: 0009-9120; 1873-2933; 1873-2933
• DOI: 10.1016/j.clinbiochem.2011.03.134

To identify systemically detectable vascular inflammation associated to redox system unbalance, advanced oxidation protein products (AOPP), formed by HClO reaction with proteins, Thiol levels, and their ratio (AOPP/Thiol ratio) were measured in patients with acute coronary syndromes (ACS). We evaluated AOPP/Thiol ratio together with CRP and IL-1β in 18 acute myocardial infarction (AMI) and in 16 unstable angina (UA) patients at admission, and in 16 control subjects (CTR); the measurements were repeated at 1 and at 6 months. At admission, AMI and UA patients displayed higher AOPP/Thiol ratio and CRP and IL-1β compared to CTR subjects. A correlation between AOPP/Thiols and IL-1β in AMI was found. At follow-up, in UA only, AOPP/Thiol ratio and IL-1β levels still remained high. The AOPP/Thiol ratio seems to affect the inflammatory process in ACS, and may represent a reliable marker of oxidative unbalance in this setting of patients.