Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations

• Published in: Journal of human genetics Vol. 68; no. 7; pp. 463 - 468
• Main Authors: Krishnan, Mohanraj, Phipps-Green, Amanda, Russell, Emily M, Major, Tanya J, Cadzow, Murray, Stamp, Lisa K, Dalbeth, Nicola, Hindmarsh, Jennie Harré, Qasim, Muhammad, Watson, Huti, Liu, Shuwei, Carlson, Jenna C, Minster, Ryan L, Hawley, Nicola L, Naseri, Take, Reupena, Muagututi'a Sefuiva, Deka, Ranjan, McGarvey, Stephen T, Merriman, Tony R, Murphy, Rinki, Weeks, Daniel E
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.07.2023
• Subjects: Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics; Bayes Theorem; Bayesian analysis; Body fat; Body Mass Index; Genetic Predisposition to Disease; Humans; Maori People - genetics; Meta-analysis; New Zealand; Pacific Island People - genetics; Polymorphism, Single Nucleotide; Statistical analysis; New Zealand
• ISSN: 1434-5161; 1435-232X
• DOI: 10.1038/s10038-023-01141-5

The fat mass and obesity associated (FTO) locus consistently associates with higher body mass index (BMI) across diverse ancestral groups. However, previous small studies of people of Polynesian ancestries have failed to replicate the association. In this study, we used Bayesian meta-analysis to test rs9939609, the most replicated FTO variant, for association with BMI with a large sample (n = 6095) of Aotearoa New Zealanders of Polynesian (Māori and Pacific) ancestry and of Samoan people living in the Independent State of Samoa and in American Samoa. We did not observe statistically significant association within each separate Polynesian subgroup. Bayesian meta-analysis of the Aotearoa New Zealand Polynesian and Samoan samples resulted in a posterior mean effect size estimate of +0.21 kg/m , with a 95% credible interval [+0.03 kg/m , +0.39 kg/m ]. While the Bayes Factor (BF) of 0.77 weakly favors the null, the BF = 1.4 Bayesian support interval is [+0.04, +0.20]. These results suggest that rs9939609 in FTO may have a similar effect on mean BMI in people of Polynesian ancestries as previously observed in other ancestral groups.