The use of PRP in treatment of Achilles Tendinopathy: A systematic review of literature. Study design: Systematic review of literature

• Published in: Annals of medicine and surgery Vol. 55; pp. 320 - 326
• Main Authors: Madhi, Mr Imad, Yausep, Oliver Emmanuel, Khamdan, Khadija, Trigkilidas, Dionysios
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2020; Elsevier
• Subjects: Review
• ISSN: 2049-0801; 2049-0801
• DOI: 10.1016/j.amsu.2020.04.042

Chronic Achilles Tendinopathy is a common condition that can be challenging to treat. There are many modalities used as treatment ranging from physiotherapy, injections, shockwave therapy to surgical intervention. Platelet Rich Plasma (PRP) has increased in popularity recently as a treatment option for Achilles Tendinopathy. It contains growth factors that might accelerate healing and speed up the recovery of this condition. Many studies have been conducted in the last few years to assess the effectiveness of this treatment method. However, there was controversy as to whether PRP had a beneficial effect on chronic Achille tendinopathy. This systematic review of the literature was conducted to ascertain the efficacy of Platelet Rich Plasma (PRP) as a treatment option in chronic Achilles tendinopathy. PRISMA reporting item for systematic review has been used to conduct the selection, Electronic databases included PubMed, EMBASE, Cochrane collaborate, Google scholar, the web of science and Cochrane Library were searched for all RCT, prospective and retrospective studies conducted between January 2010 to February 2019. The quality of each study was evaluated using the Oxford CEBM tool to assess the articles for validity, relevance, and applicability of the results. A total number of 288 were found, and only 11 met the inclusion criteria. 5 Randomised control trials, 4 prospective and 2 retrospective cohort study were included in this systematic review. A total number of 406 patients were treated for non-insertional Achilles tendinopathy of which 230 patients had PRP local injection under Ultrasound guide. Although many of the retrospective studies suggested an advantage of using PRP, the higher level of evidence studies do not support a significant efficacy. This systematic review showed very promising results from the use of Platelet Rich Plasma demonstrated by a significant improvement in the VAST-A score, but we certainly need decent size randomised control trials to show better and more accurate results. •Platelet rich plasma (PRP) has increased in popularity as a treatment option for Achilles Tendinopathy as it contains growth factors that might accelerate healing and speed up the recovery of this condition.•Results of this systematic review showed significant improvement in the VISA-A score of the overall studies 28.9 point, comparing the VISA-A score using PRP with the most recent systematic review studied the effectiveness of heavy eccentric calf training (Murphy et al., 2019) [20].•Most of the RCTs were characterised by their small sample sizes which might resulted in the insignificant results.