Nodular sclerosing Hodgkin's disease and large cell lymphoma. Immunophenotypic characterization of a composite case

Composite lymphomas have rarely been reported in Hodgkin's disease (HD), except in the lymphocyte predominance sub-type, and immunohistochemical investigations have been performed in only few cases. We describe the histological and immunophenotypical findings in a case of composite nodular scle...

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Bibliographic Details
Published inVirchows Archiv. A, Pathological anatomy and histopathology Vol. 421; no. 3; p. 271
Main Authors Paulli, M, Rosso, R, Kindl, S, Boveri, E, Sirchi, M, De Medici, A, Invernizzi, R, Magrini, U
Format Journal Article
LanguageEnglish
Published Germany 1992
Subjects
Adult
Antigens, CD - analysis
Antigens, CD20
Antigens, Differentiation, B-Lymphocyte - analysis
Antineoplastic Agents - administration & dosage
Histocompatibility Antigens Class II - analysis
HLA-DR Antigens - analysis
Hodgkin Disease - pathology
Humans
Lewis X Antigen
Lymphoma, Large B-Cell, Diffuse - pathology
Lymphoma, Non-Hodgkin - pathology
Male
Membrane Glycoproteins - analysis
Mucin-1
Neoplasms, Multiple Primary - pathology
Phenotype
Sialyltransferases - analysis
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Summary:Composite lymphomas have rarely been reported in Hodgkin's disease (HD), except in the lymphocyte predominance sub-type, and immunohistochemical investigations have been performed in only few cases. We describe the histological and immunophenotypical findings in a case of composite nodular sclerosing HD and high-grade, large cell non-Hodgkin's lymphoma (NHL). In our case HD and NHL cells displayed striking morphological and immunophenotypical divergence, suggesting a lack of correlation between the two neoplasms.
ISSN:0174-7398
DOI:10.1007/bf01611185