A redox-activated theranostic nanoagent: toward multi-mode imaging guided chemo-photothermal therapy

• Published in: Chemical science (Cambridge) Vol. 9; no. 33; pp. 6749 - 6757
• Main Authors: Zhang, Ting-Ting, Xu, Cong-Hui, Zhao, Wei, Gu, Yu, Li, Xiang-Ling, Xu, Jing-Juan, Chen, Hong-Yuan
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 07.09.2018
• Subjects: Anticancer properties; Blood flow; Cancer; Cancer therapies; Chemistry; Chemotherapy; Drug delivery systems; Fluorescence; Glutathione; Gold; Hypoxia; Infrared radiation; Light irradiation; Magnetic resonance imaging; Manganese dioxide; Manganese ions; Medical imaging; NMR; Nuclear magnetic resonance; Tumors

Development of tumor microenvironment responsive and modulating theranostic nano-systems is of great importance for specific and efficient cancer therapy. Herein, we report a redox-sensitive nanoagent combining manganese dioxide (MnO 2 ) and gold nanoshell coated silicon nanoparticles for synergisti...