A redox-activated theranostic nanoagent: toward multi-mode imaging guided chemo-photothermal therapy

Development of tumor microenvironment responsive and modulating theranostic nano-systems is of great importance for specific and efficient cancer therapy. Herein, we report a redox-sensitive nanoagent combining manganese dioxide (MnO 2 ) and gold nanoshell coated silicon nanoparticles for synergisti...

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Published inChemical science (Cambridge) Vol. 9; no. 33; pp. 6749 - 6757
Main Authors Zhang, Ting-Ting, Xu, Cong-Hui, Zhao, Wei, Gu, Yu, Li, Xiang-Ling, Xu, Jing-Juan, Chen, Hong-Yuan
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 07.09.2018
Subjects
Anticancer properties
Blood flow
Cancer
Cancer therapies
Chemistry
Chemotherapy
Drug delivery systems
Fluorescence
Glutathione
Gold
Hypoxia
Infrared radiation
Light irradiation
Magnetic resonance imaging
Manganese dioxide
Manganese ions
Medical imaging
NMR
Nuclear magnetic resonance
Tumors
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Summary:Development of tumor microenvironment responsive and modulating theranostic nano-systems is of great importance for specific and efficient cancer therapy. Herein, we report a redox-sensitive nanoagent combining manganese dioxide (MnO 2 ) and gold nanoshell coated silicon nanoparticles for synergistic chemo-photothermal therapy of hypoxia solid tumors. In highly reducing tumor tissues, the outer MnO 2 nanosheet with the loaded drug would be dissociated by intracellular glutathione (GSH), resulting in on-demand drug release, as well as generating Mn 2+ ions which provided high contrast magnetic resonance imaging (MRI), and fluorescence imaging (FI) in vitro and in vivo . While upon near-infrared (NIR) light irradiation, the gold nanoshell modulated the hypoxic tumor microenvironment via increasing blood flow, achieving enhanced photothermal therapy (PTT) and chemotherapy. After tail vein injection into tumor-bearing mice and monitoring in real time, the intelligent redox-activated nanoagent exhibited high tumor accumulation and powerful synergistic chemo-photothermal therapy efficiency. The proposed work developed a noninvasive strategy to modulate the tumor microenvironment and enhance the anticancer therapeutic effect. We believe that this single nano-platform exhibits promising potential as a comprehensive theranostic agent to enhance the efficacies of synergistic cancer therapy.
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These authors contributed equally to the work.
ISSN:2041-6520
2041-6539
DOI:10.1039/C8SC02446D