Factors Associated with Disease Survival after Surgical Resection in Chinese Patients with Hepatocellular Carcinoma

• Published in: World journal of surgery Vol. 30; no. 3; pp. 439 - 445
• Main Authors: Qiang, Li, Huikai, Li, Butt, Kelly, Wang, P. Peter, Hao, Xishan
• Format: Journal Article
• Language: English
• Published: New York Springer‐Verlag 01.03.2006; Springer; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Anatomical Resection; Biological and medical sciences; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - surgery; China - epidemiology; Disease-Free Survival; Extended Hepatectomy; Female; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Hepatectomy; Hepatic Resection; Humans; Liver Neoplasms - mortality; Liver Neoplasms - surgery; Liver Resection; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Proportional Hazards Models; Survival Rate; Treatment Outcome; Tumors; Vascular Invasion; Asia; China; Human; Asiatic; Disease; Hepatic disease; Hepatocellular carcinoma; Patient; Surgical resection; Malignant tumor; Survival; Medicine; Treatment; Surgery; Risk factor; Digestive diseases; Chinese
• ISSN: 0364-2313; 1432-2323
• DOI: 10.1007/s00268-005-0608-6

Objective The aim of this cohort study was to investigate clinical outcome and prognostic factors after surgical resection for hepatocellular carcinoma (HCC). Materials and Methods A total of 1,157 HCC patients undergoing hepatic resection between 1998 and 2003 were included in this study. Univariate and multivariate analyses were performed to examine factors affecting clinical outcome and recurrence. Results Surgical procedures consisted of 1,011 (87.4%) anatomical resections, including 205 (17.7%) extended hepatectomies, 324 (28.0%) hemihepatectomies, 482 (41.7%) segmental resections, and 146 (12.6%) local resections. The results suggest that 56.6% of patients had a recurrence of HCC during the study period and the main recurrence type was intrahepatic (542; 83.1%). The median survival time was 45 months. The 1‐, 3‐ and 5‐year overall disease‐free survival rates for the study population were 74%, 47%, and 39% respectively. Conclusions The results of proportional hazard analyses suggest that tumor size, number of nodules and vascular invasion were significant predictors for poor survival rates.