Characterization of a Ruthenium(III)/NAMI-A Adduct with Bovine Serum Albumin that Exhibits a High Anti-Metastatic Activity

An exchange for the better: X‐ray absorption spectroscopic studies show that treatment of an RuIII drug, NAMI‐A, with bovine serum albumin (BSA) results in complete replacement of the Cl− and S‐donor ligands with N‐donor and carboxylato residues of the protein (see scheme). The RuIII–BSA adduct is a...

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Published inAngewandte Chemie (International ed.) Vol. 49; no. 9; pp. 1661 - 1664
Main Authors Liu, Mimi, Lim, Zhi Jun, Gwee, Yee Yen, Levina, Aviva, Lay, Peter A
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 22.02.2010
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - toxicity
antitumor agents
biotransformations
Cattle
Cell Line, Tumor
Coordination Complexes - chemistry
Coordination Complexes - toxicity
Dimethyl Sulfoxide - analogs & derivatives
Dimethyl Sulfoxide - chemistry
Humans
Organometallic Compounds - chemistry
prodrugs
ruthenium
Ruthenium - chemistry
Serum Albumin, Bovine - chemistry
X-Ray Absorption Spectroscopy
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Summary:An exchange for the better: X‐ray absorption spectroscopic studies show that treatment of an RuIII drug, NAMI‐A, with bovine serum albumin (BSA) results in complete replacement of the Cl− and S‐donor ligands with N‐donor and carboxylato residues of the protein (see scheme). The RuIII–BSA adduct is as active in enhancing the cell–substrate interactions as the original NAMI‐A complex (which converts into RuIII–BSA within minutes in the cell‐culture medium).
Bibliography:http://dx.doi.org/10.1002/anie.200906079
ArticleID:ANIE200906079
ark:/67375/WNG-L8WBNTDX-R
The research has been supported by the Australian Research Council Discovery and LIEF grants (including ARC Professorial Fellowships) to P.A.L. X-ray absorption spectroscopy was performed at the Australian National Beamline Facility (Photon Factory, Tsukuba (Japan)) with support from the Australian Synchrotron Research Program (see Supporting Information for more acknowledgements).
Australian Research Council Discovery
LIEF
istex:5D0B0594574314132E57028DF7C1666495CB5986
The research has been supported by the Australian Research Council Discovery and LIEF grants (including ARC Professorial Fellowships) to P.A.L. X‐ray absorption spectroscopy was performed at the Australian National Beamline Facility (Photon Factory, Tsukuba (Japan)) with support from the Australian Synchrotron Research Program (see Supporting Information for more acknowledgements).
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200906079