Effects of Inhaled Nitric Oxide on Postoperative Pulmonary Circulation in Patients with Congenital Heart Disease

• Published in: Artificial organs Vol. 21; no. 1; pp. 17 - 20
• Main Authors: Matsui, Junki, Yahagi, Naoki, Kumon, Keiji, Hayashi, Hideaki, Watanabe, Yasuhiko, Haruna, Masaki, Tanigami, Hironobu, Yagihara, Toshikatsu, Takamoto, Shinichi, Kamiya, Tetsuro
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.1997
• Subjects: Administration, Inhalation; Cardiac surgery; Cardiopulmonary Bypass - adverse effects; Congenital heart disease; Female; Heart Defects, Congenital - physiopathology; Heart Defects, Congenital - surgery; Hemoglobins - analysis; Humans; Hypertension, Pulmonary - drug therapy; Infant; Infant, Newborn; Male; Nitric oxide; Nitric Oxide - administration & dosage; Nitric Oxide - pharmacology; Nitric Oxide - therapeutic use; Postoperative Complications - prevention & control; Pulmonary Circulation - drug effects; Pulmonary hypertension; Pulmonary hypertensive crises; Vasodilator Agents - administration & dosage; Vasodilator Agents - pharmacology; Vasodilator Agents - therapeutic use
• ISSN: 0160-564X; 1525-1594
• DOI: 10.1111/j.1525-1594.1997.tb00692.x

: We studied 22 patients with residual pulmonary hypertension or symptoms of postoperative pulmonary hypertensive crisis. They received low‐dose inhalation (10 ppin) of nitric oxide (NO). a selective pulmonary vasodilator, after total correction for ccingenital heart anomalies. Fifteen minutes of NO inhalation improved the pulmonary circulation and lessened the imbalance in the ventilation‐perfusion ratio in both groups. Thus, NO inhalation is effective in the treatment of pulmonary hypertension and in the prevention of pulmonary hypertensive crises after total correction for congenital heart anomalies. All patients continued to receive NO therapeuti‐cally. The duration of such therapeutic NO inhalation was well correlated with postoperative Qp/Qs (p = 0.014) and RpRs (p = 0.029).