Epidermal growth factor receptors and oestrogen receptors in the head and neck

We report a pilot study of the levels of epidermal growth factor receptors (EGFR) in normal and neoplastic tissues of the head and neck. Specimens from 20 consecutive patients undergoing major head and neck surgery showed that squamous cell carcinomas had detectable but widely varying levels of EGFR...

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Bibliographic Details
Published inClinical otolaryngology and allied sciences Vol. 18; no. 1; p. 66
Main Authors Wilson, J A, Rogers, M J, Hawkins, R A, Gilmour, H M, Maran, A G
Format Journal Article
LanguageEnglish
Published England 01.02.1993
Subjects
ErbB Receptors - analysis
Female
Head and Neck Neoplasms - chemistry
Humans
Male
Middle Aged
Pilot Projects
Receptors, Estrogen - analysis
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Summary:We report a pilot study of the levels of epidermal growth factor receptors (EGFR) in normal and neoplastic tissues of the head and neck. Specimens from 20 consecutive patients undergoing major head and neck surgery showed that squamous cell carcinomas had detectable but widely varying levels of EGFR. EGFR expression was greater in normal salivary gland tissue than in benign salivary neoplasms. Oestrogen receptors were not detected in clinically significant amounts in any of the tumours assayed.
ISSN:0307-7772
DOI:10.1111/j.1365-2273.1993.tb00813.x