The genome of a clinical Klebsiella variicola strain reveals virulence-associated traits and a pl9-like plasmid

• Published in: FEMS microbiology letters Vol. 360; no. 1; pp. 13 - 16
• Main Authors: Andrade, Bruno Gabriel N., de Veiga Ramos, Nilceia, Marin, Michel F. Abanto, Fonseca, Erica L., Vicente, Ana Carolina P.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2014; Oxford University Press
• Subjects: DNA, Bacterial - genetics; Drug Resistance, Bacterial - genetics; Genome, Bacterial - genetics; Humans; Klebsiella - genetics; Klebsiella - pathogenicity; Klebsiella Infections - microbiology; Klebsiella pneumoniae - genetics; Klebsiella virulence determinants; Microbiology; mobilome; penicillin resistant; Plasmids; Virulence; Virulence Factors - genetics; whole genome sequencing; whole genome sequencing; virulence determinants; penicillin resistant; mobilome
• ISSN: 0378-1097; 1574-6968
• DOI: 10.1111/1574-6968.12583

Abstract Klebsiella species frequently cause clinically relevant human infections worldwide. We report the draft genome sequence of a Brazilian clinical isolate (Bz19) of the recently recognized species Klebsiella variicola. The comparison of Bz19 genome content with the At-22 (environmental K. variicola) and several clinical Klebsiella pneumoniae shows that these species share a set of virulence-associated determinants. Of note, this K. variicola strain harbours a plasmid-like element that shares the same backbone present in a multidrug-resistant plasmid found in a clinical K. pneumoniae isolated in USA. This manuscript reports the genome sequence of a clinical Klebsiella variicola isolate, and its comparison to other completely sequenced Klebsiella species. This manuscript reports the genome sequence of a clinical Klebsiella variicola isolate, and its comparison to other completely sequenced Klebsiella species.