Mesangio-capillary glomerulonephritis associated with Q-fever endocarditis

A patient with nephrotic syndrome and Q-fever endocarditis (confirmed serologically and ultrastructurally) was found to have mesangio-capillary glomerulonephritis with parietal deposits of C3 and IgM and some IgM in the mesangium. Elution studies showed that IgM antibodies reactive against insoluble...

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Bibliographic Details
Published inHistopathology Vol. 1; no. 6; p. 463
Main Authors Uff, J S, Evans, D J
Format Journal Article
LanguageEnglish
Published England 01.11.1977
Subjects
Adult
Antibodies, Bacterial
Coxiella - immunology
Endocarditis, Bacterial - complications
Endocarditis, Bacterial - pathology
Female
Glomerulonephritis - etiology
Glomerulonephritis - immunology
Glomerulonephritis - pathology
Humans
Immunoglobulin G
Immunoglobulin M
Kidney - pathology
Q Fever - complications
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Summary:A patient with nephrotic syndrome and Q-fever endocarditis (confirmed serologically and ultrastructurally) was found to have mesangio-capillary glomerulonephritis with parietal deposits of C3 and IgM and some IgM in the mesangium. Elution studies showed that IgM antibodies reactive against insoluble Coxiella antigens were present in the kidney. Review of the literature suggests that this type of immune complex nephritis may be associated with Q-fever. Possible reasons for the variability of the nephritis associated with infective endocarditis are discussed.
ISSN:0309-0167
DOI:10.1111/j.1365-2559.1977.tb01685.x