The significance of vertical mitosis in epidermis

In normal epidermis mitosis usually occurs in a plane horizontal to the dermo-epidermal junction, both daughter cells then remaining basal while an adjacent non-mitotic cell is detached from the baseline and forced distally. The evidence now indicates that only cells in a certain intermitotic state,...

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Bibliographic Details
Published inBritish journal of dermatology (1951) Vol. 99; no. 6; p. 603
Main Authors Bullough, W S, Mitrani, E N
Format Journal Article
LanguageEnglish
Published England 01.12.1978
Subjects
Animals
Biometry
Duodenum - cytology
Ear - pathology
Epidermal Cells
Epidermis - pathology
Epithelial Cells
Foot
Guinea Pigs
Hair
Hyperplasia
Intestinal Mucosa - cytology
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mitosis
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Summary:In normal epidermis mitosis usually occurs in a plane horizontal to the dermo-epidermal junction, both daughter cells then remaining basal while an adjacent non-mitotic cell is detached from the baseline and forced distally. The evidence now indicates that only cells in a certain intermitotic state, called GIb, can be thus detached, and that when such cells are not locally available the expanding mitosis is forced into the vertical axis. The higher the mitotic rate the shorter is the intermitotic interval, and therefore the less probable it becomes that GIb cells will be locally available for extrusion and the more probable that mitosis will take place vertically. At the highest mitotic rates, as in hair bulbs, all mitoses are vertical. The relation of these findings to epidermal structure and to epidermal cellular homeostasis is discussed.
ISSN:0007-0963
DOI:10.1111/j.1365-2133.1978.tb07053.x