A decade-long sour-taste sensation successfully treated with a proton-pump inhibitor

• Published in: Journal of oral rehabilitation Vol. 32; no. 10; pp. 776 - 778
• Main Authors: MANTANI, N., ITO, K., KOGURE, T., HOSHINO, A., KAWADA, E., SAKAMOTO, H., FUJITA, K., TAMURA, J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.10.2005
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles; Dentistry; Drug Administration Schedule; Enzyme Inhibitors - administration & dosage; Female; gastro-oesophageal reflux disease; Gastroesophageal Reflux; Humans; Lansoprazole; Middle Aged; Omeprazole - administration & dosage; Omeprazole - analogs & derivatives; Proton Pump Inhibitors; proton-pump inhibitor; sour taste; Taste Disorders - drug therapy; Treatment Outcome
• ISSN: 0305-182X; 1365-2842
• DOI: 10.1111/j.1365-2842.2005.01492.x

summary We report a case study of a 54‐year‐old Japanese woman who persistently suffered from a sour‐taste sensation in her mouth for 10 years, and was treated with a proton‐pump inhibitor (PPI). She found sour‐tasting meals irritable, and after eating such meals the sour‐taste sensation worsened. She also complained of eructation and regurgitation. Upper gastrointestinal (GI) endoscopy showed duodenal erosion, superficial gastritis, and erosive oesophagitis. After 2 weeks of PPI therapy (lansoprazole, 30 mg day−1) the sour taste subjectively decreased to 70%, and after 6 weeks the symptoms disappeared. In addition to increased sensitivity of the mouth, gastro‐oesophageal reflux might have created her obstinate sour‐taste sensations. It is suggested that in such cases PPI therapy should be attempted.