Amyloid arthropathy in myelomatosis--intracytoplasmic synovial deposition

An unusual case is described of a West Indian man who presented with symptoms of an acute polyarthritis and who was found to have myelomatosis. At necropsy, generalized amyloidosis was found with particular involvement of synovial tissue. Myelomatosis presenting as an acute polyarthritis resembling...

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Bibliographic Details
Published inHistopathology Vol. 4; no. 1; p. 21
Main Author French, B T
Format Journal Article
LanguageEnglish
Published England 01.01.1980
Subjects
Amyloid - analysis
Amyloidosis - complications
Arthritis - etiology
Cytoplasm - analysis
Humans
Joint Diseases - complications
Joint Diseases - immunology
Joint Diseases - pathology
Male
Microscopy, Electron
Middle Aged
Multiple Myeloma - complications
Multiple Myeloma - immunology
Multiple Myeloma - pathology
Synovial Membrane - analysis
Synovial Membrane - pathology
Synovial Membrane - ultrastructure
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Summary:An unusual case is described of a West Indian man who presented with symptoms of an acute polyarthritis and who was found to have myelomatosis. At necropsy, generalized amyloidosis was found with particular involvement of synovial tissue. Myelomatosis presenting as an acute polyarthritis resembling rheumatoid arthritis is an uncommon, although well recognized entity, whereas an arthritic picture produced by amyloidosis is exceptional. The occurrence of joint pathology in myelomatosis and amyloidosis is discussed and the unique feature of intracytoplasmic amyloid deposition seen in this case is stressed.
ISSN:0309-0167
DOI:10.1111/j.1365-2559.1980.tb02894.x