Kininogen and kininogenase synthesis by the liver of normal and injured rats

Isolated livers from normal rats or from others at 2 days after subcutaneous injection of turpentine have been perfused with a simplified medium. Estimation of kininogen, kininogenase and 2 plasma proteins in the perfusates thus obtained indicate that both kininogen and kininogenase are synthesized...

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Bibliographic Details
Published inJournal of pharmacy and pharmacology Vol. 28; no. 1; p. 44
Main Authors Borges, D R, Gordon, A H
Format Journal Article
LanguageEnglish
Published England 01.01.1976
Subjects
Animals
Blood Proteins - metabolism
Chemical and Drug Induced Liver Injury - enzymology
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - metabolism
In Vitro Techniques
Kallikreins - biosynthesis
Kininogens - biosynthesis
Liver - enzymology
Liver - metabolism
Rats
Time Factors
Turpentine
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Summary:Isolated livers from normal rats or from others at 2 days after subcutaneous injection of turpentine have been perfused with a simplified medium. Estimation of kininogen, kininogenase and 2 plasma proteins in the perfusates thus obtained indicate that both kininogen and kininogenase are synthesized in the liver. Furthermore, because twice as much kininogen and kininogenase was synthesized by the livers from the rats which had been injected with turpentine as by those from the normal rats, these two proteins must be considered to be members of the group of plasma proteins known as acute phase reactants.
ISSN:0022-3573
DOI:10.1111/j.2042-7158.1976.tb04021.x