Polyacrylate Dendrimer Nanoparticles: A Self-Adjuvanting Vaccine Delivery System

Special delivery: An effective group A streptococci vaccine is formed from a delivery device consisting of well‐defined dendritic structures with nanoscale dimensions (see picture). The structures are designed to display multiple copies of the minimal B‐cell epitopes, which were in the optimal confo...

Full description

Saved in:
Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 49; no. 33; pp. 5742 - 5745
Main Authors Skwarczynski, Mariusz, Zaman, Mehfuz, Urbani, Carl N, Lin, I. Chun, Jia, Zhongfan, Batzloff, Michael R, Good, Michael F, Monteiro, Michael J, Toth, Istvan
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 02.08.2010
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
Acrylic Resins - chemistry
Amino Acid Sequence
amphiphiles
Copper - chemistry
dendrimers
Dendrimers - chemistry
Drug Carriers - chemistry
drug delivery
Humans
Molecular Sequence Data
nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Rheumatic Heart Disease - prevention & control
self-assembly
Streptococcal Vaccines - administration & dosage
Streptococcal Vaccines - immunology
Online AccessGet full text

Cover

More Information
Summary:Special delivery: An effective group A streptococci vaccine is formed from a delivery device consisting of well‐defined dendritic structures with nanoscale dimensions (see picture). The structures are designed to display multiple copies of the minimal B‐cell epitopes, which were in the optimal conformation on the surface of the nanoparticles. The nanoparticles can be administered without the aid of an adjuvant.
Bibliography:http://dx.doi.org/10.1002/anie.201002221
This work was supported by the National Health and Medical Research Council. We thank George Blazak at the University of Queensland, Australia, for performing elemental analysis, and Dr. M. Georgousakis from QIMR for providing us with IgG J14 antibody.
National Health and Medical Research Council
ark:/67375/WNG-H78K8HN5-7
ArticleID:ANIE201002221
istex:A224622C195AAE8BDD5652A97FB1B6425FC12339
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201002221