Infantile haemangiomas: a challenge in paediatric dermatology
Infantile haemangiomas, common benign vascular tumours of childhood, are characterized by rapid growth during the first year of life and a slow regression that is usually completed at 7–10 years of age. These tumours are composed of endothelial cells with high mitotic rates and stromal components su...
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Published in | Journal of the European Academy of Dermatology and Venereology Vol. 24; no. 6; pp. 631 - 638 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.06.2010
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Subjects | |
Online Access | Get full text |
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Summary: | Infantile haemangiomas, common benign vascular tumours of childhood, are characterized by rapid growth during the first year of life and a slow regression that is usually completed at 7–10 years of age. These tumours are composed of endothelial cells with high mitotic rates and stromal components such as fibroblasts, mast cells and pericytes. Haemangiomas become a challenge when they are part of a syndrome, are located in certain areas of the body or when complications develop. The above‐mentioned factors also influence the treatment modality used. However, although there remain many uncertainties regarding management, the β‐adrenergic receptor blocker propranolol is a promising new candidate for first‐line systemic therapy. It produces such a dramatic and rapid response that the appearance of an infantile haemangioma should impart expeditious consideration of the risks and benefits of its use. |
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Bibliography: | ArticleID:JDV3650 istex:526A96846B4A5FA91C72164DBAAB4E26E6CF1288 ark:/67375/WNG-THCFD3WF-9 Conflict of interest None declared. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0926-9959 1468-3083 |
DOI: | 10.1111/j.1468-3083.2010.03650.x |