Nontuberculous mycobacterial lung disease in patients without HIV infection: a retrospective analysis over 3 years
Introduction: Nontuberculous mycobacterial lung infections are relatively common in immunocompromised patients but are now increasingly being diagnosed in immunocompetent individuals. These organisms are not always pathogenic bacteria when isolated from human samples. The identification of which is...
Saved in:
Published in | The clinical respiratory journal Vol. 5; no. 4; pp. 203 - 210 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.10.2011
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Introduction: Nontuberculous mycobacterial lung infections are relatively common in immunocompromised patients but are now increasingly being diagnosed in immunocompetent individuals. These organisms are not always pathogenic bacteria when isolated from human samples. The identification of which isolates are contaminants or colonizers is based on internationally accepted criteria. The clinical significance of the isolation of nontuberculous mycobacteria (NTM) from respiratory specimens in Italy is unknown.
Objective: study was performed to evaluate the local epidemiology of NTM pulmonary infection in Naples in patients with positive respiratory specimens, and also to describe the clinical and radiological features of NTM pulmonary disease in immunocompetent patients with or without pre‐existing lung disease.
Methods: Between December 2006 and September 2009, the clinical records and radiological examinations of 39 patients with 55 positive cultures for NTM species by sputum or bronchial wash or lavage were reviewed.
Results: According to microbiological, clinical and radiological criteria, our study identified 16 patients with NTM lung infection as a ‘disease’ group and 23 patients in a ‘contamination’ group but without disease. M. intracellulare (n = 7, 41.2%), followed by M. kansasii (n = 5, 29.4%) were the most common NTM found in the ‘disease’ group. We detected a high number of M. gordonae isolates in respiratory samples obtained by fibrobronchoscopy.
Conclusions: We evaluated the clinical significance of isolations in our reference centre in Naples. Forty‐one of all patients have ‘disease’, M. intracellulare and M. kansasii are mainly responsible. NTM species were analyzed in relation to their frequency. Assumptions were made about low pathogenic NTM isolations.
Please cite this paper as: Del Giudice G, Iadevaia C, Santoro G, Moscariello E, Smeraglia R and Marzo C. Nontuberculous mycobacterial lung disease in patients without HIV infection: a retrospective analysis over 3 years. Clin Respir J 2011; 5:203–210. |
---|---|
Bibliography: | ArticleID:CRJ220 ark:/67375/WNG-4038CL94-T istex:6F5E77DD6A1227A198E37DF05E48AA8E6325905E Ethics Ginevra Del Giudice: main author, designed study and analyzed data. Carlo Iadevaia: performed study, collected data and wrote paper. Giulia Santoro: performed isolation and tipization of mycobacteria form specimen, collected data. Emilio Moscariello: analyzed data. Riccardo Smeraglia: analyzed data. Carlo Marzo: designed study and analyzed data. Authorship The authors have stated explicitly that there are no conflicts of interest in connection with this article. Radiological and laboratory data were obtained by review of medical records. The personal data of patients were appropriately omitted. No drug was administered during the study. No diagnostic procedure was performed without informed consent. Conflict of interest ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1752-6981 1752-699X |
DOI: | 10.1111/j.1752-699X.2010.00220.x |