Catalytic antibodies: balancing between Dr. Jekyll and Mr. Hyde

The immunoglobulin molecule is a perfect template for the de novo generation of biocatalytic functions. Catalytic antibodies, or abzymes, obtained by the structural mimicking of enzyme active sites have been shown to catalyze numerous chemical reactions. Natural enzyme analogs for some of these reac...

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Published in	BioEssays Vol. 31; no. 11; pp. 1161 - 1171
Main Authors	Belogurov, Alexey Jr, Kozyr, Arina, Ponomarenko, Natalia, Gabibov, Alexander
Format	Journal Article
Language	English
Published	Weinheim Wiley-VCH Verlag 01.11.2009 WILEY-VCH Verlag WILEY‐VCH Verlag
Subjects	abzymes Alzheimer Disease - immunology Animals anti-DNA antibodies Antibodies, Catalytic - chemistry Antibodies, Catalytic - physiology Autoimmunity Biochemistry - methods catalytic vaccines Diabetes Mellitus - immunology Factor VIII - physiology Humans Immunoglobulins - chemistry Models, Biological Multiple Sclerosis - immunology Protein Engineering - methods Sepsis - immunology Thyroiditis - immunology transition state Vaccines
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Abstract	The immunoglobulin molecule is a perfect template for the de novo generation of biocatalytic functions. Catalytic antibodies, or abzymes, obtained by the structural mimicking of enzyme active sites have been shown to catalyze numerous chemical reactions. Natural enzyme analogs for some of these reactions have not yet been found or possibly do not exist at all. Nowadays, the dramatic breakthrough in antibody engineering and expression technologies has promoted a considerable expansion of immunoglobulin's medical applications and is offering abzymes a unique chance to become a promising source of high-precision "catalytic vaccines." At the same time, the discovery of natural abzymes on the background of autoimmune disease revealed their beneficial and pathogenic roles in the disease progression. Thus, the conflicting Dr. Jekyll and Mr. Hyde protective and destructive essences of catalytic antibodies should be carefully considered in the development of therapeutic abzyme applications.
AbstractList	The immunoglobulin molecule is a perfect template for the de novo generation of biocatalytic functions. Catalytic antibodies, or abzymes, obtained by the structural mimicking of enzyme active sites have been shown to catalyze numerous chemical reactions. Natural enzyme analogs for some of these reactions have not yet been found or possibly do not exist at all. Nowadays, the dramatic breakthrough in antibody engineering and expression technologies has promoted a considerable expansion of immunoglobulin's medical applications and is offering abzymes a unique chance to become a promising source of high-precision "catalytic vaccines." At the same time, the discovery of natural abzymes on the background of autoimmune disease revealed their beneficial and pathogenic roles in the disease progression. Thus, the conflicting Dr. Jekyll and Mr. Hyde protective and destructive essences of catalytic antibodies should be carefully considered in the development of therapeutic abzyme applications. Abstract The immunoglobulin molecule is a perfect template for the de novo generation of biocatalytic functions. Catalytic antibodies, or abzymes, obtained by the structural mimicking of enzyme active sites have been shown to catalyze numerous chemical reactions. Natural enzyme analogs for some of these reactions have not yet been found or possibly do not exist at all. Nowadays, the dramatic breakthrough in antibody engineering and expression technologies has promoted a considerable expansion of immunoglobulin's medical applications and is offering abzymes a unique chance to become a promising source of high‐precision “catalytic vaccines.” At the same time, the discovery of natural abzymes on the background of autoimmune disease revealed their beneficial and pathogenic roles in the disease progression. Thus, the conflicting Dr. Jekyll and Mr. Hyde protective and destructive essences of catalytic antibodies should be carefully considered in the development of therapeutic abzyme applications.
Author	Gabibov, Alexander Kozyr, Arina Belogurov, Alexey Jr Ponomarenko, Natalia
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Snippet	The immunoglobulin molecule is a perfect template for the de novo generation of biocatalytic functions. Catalytic antibodies, or abzymes, obtained by the... Abstract The immunoglobulin molecule is a perfect template for the de novo generation of biocatalytic functions. Catalytic antibodies, or abzymes, obtained by...
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SubjectTerms	abzymes Alzheimer Disease - immunology Animals anti-DNA antibodies Antibodies, Catalytic - chemistry Antibodies, Catalytic - physiology Autoimmunity Biochemistry - methods catalytic vaccines Diabetes Mellitus - immunology Factor VIII - physiology Humans Immunoglobulins - chemistry Models, Biological Multiple Sclerosis - immunology Protein Engineering - methods Sepsis - immunology Thyroiditis - immunology transition state Vaccines
Title	Catalytic antibodies: balancing between Dr. Jekyll and Mr. Hyde
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