Catalytic antibodies: balancing between Dr. Jekyll and Mr. Hyde

• Published in: BioEssays Vol. 31; no. 11; pp. 1161 - 1171
• Main Authors: Belogurov, Alexey Jr, Kozyr, Arina, Ponomarenko, Natalia, Gabibov, Alexander
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley-VCH Verlag 01.11.2009; WILEY-VCH Verlag; WILEY‐VCH Verlag
• Subjects: abzymes; Alzheimer Disease - immunology; Animals; anti-DNA antibodies; Antibodies, Catalytic - chemistry; Antibodies, Catalytic - physiology; Autoimmunity; Biochemistry - methods; catalytic vaccines; Diabetes Mellitus - immunology; Factor VIII - physiology; Humans; Immunoglobulins - chemistry; Models, Biological; Multiple Sclerosis - immunology; Protein Engineering - methods; Sepsis - immunology; Thyroiditis - immunology; transition state; Vaccines
• ISSN: 0265-9247; 1521-1878
• DOI: 10.1002/bies.200900020

The immunoglobulin molecule is a perfect template for the de novo generation of biocatalytic functions. Catalytic antibodies, or abzymes, obtained by the structural mimicking of enzyme active sites have been shown to catalyze numerous chemical reactions. Natural enzyme analogs for some of these reactions have not yet been found or possibly do not exist at all. Nowadays, the dramatic breakthrough in antibody engineering and expression technologies has promoted a considerable expansion of immunoglobulin's medical applications and is offering abzymes a unique chance to become a promising source of high-precision "catalytic vaccines." At the same time, the discovery of natural abzymes on the background of autoimmune disease revealed their beneficial and pathogenic roles in the disease progression. Thus, the conflicting Dr. Jekyll and Mr. Hyde protective and destructive essences of catalytic antibodies should be carefully considered in the development of therapeutic abzyme applications.