Impaired response to pneumococcal vaccine in systemic lupus erythematosus

An immunization program with pneumococcal vaccine was carried out in 38 patients with systemic lupus erythematosus (SLE). Mean antibody levels at 1 month and 1 year were significantly lower than in normal controls. This decreased response did not correlate with drug therapy at the time of immunizati...

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Bibliographic Details
Published inArthritis and rheumatism Vol. 23; no. 11; p. 1287
Main Authors Jarrett, M P, Schiffman, G, Barland, P, Grayzel, A I
Format Journal Article
LanguageEnglish
Published United States 01.11.1980
Subjects
Adult
Antibodies, Bacterial - analysis
Antibody Formation
Bacterial Vaccines - immunology
Humans
Hypersensitivity, Delayed
Immunization
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Lupus Erythematosus, Systemic - drug therapy
Lupus Erythematosus, Systemic - immunology
Pneumococcal Infections - prevention & control
Streptococcus pneumoniae - immunology
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Summary:An immunization program with pneumococcal vaccine was carried out in 38 patients with systemic lupus erythematosus (SLE). Mean antibody levels at 1 month and 1 year were significantly lower than in normal controls. This decreased response did not correlate with drug therapy at the time of immunization. Other parameters such as anergy state, renal function, and serum immunoglobulin levels also did not correlate with antibody response. There were no adverse effects noted in the vaccinated group in comparison to matched non-vaccinated SLE patients.
ISSN:0004-3591
DOI:10.1002/art.1780231110