The tongue features associated with chronic kidney disease

• Published in: Medicine (Baltimore) Vol. 100; no. 9; p. e25037
• Main Authors: Chen, Jia-Ming, Chiu, Ping-Fang, Wu, Feng-Mei, Hsu, Po-Chi, Deng, Li-Jyun, Chang, Chia-Chu, Chiang, John Y, Lo, Lun-Chien
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 05.03.2021
• Subjects: Adult; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Male; Medicine, Chinese Traditional - methods; Renal Insufficiency, Chronic - complications; Study Protocol Clinical Trial; Tongue - pathology; Tongue Diseases - diagnosis; Tongue Diseases - etiology; Tongue Diseases - pathology; Young Adult
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000025037

Traditional Chinese medicine (TCM) tongue diagnosis plays an important role in differentiation of symptoms because the tongue reflects the physiological and pathological condition of the body. The automatic tongue diagnosis system (ATDS), which noninvasively captures tongue images, can provide objective and reliable diagnostic information. Chronic kidney disease (CKD) currently is an important global public health problem and contributor to morbidity and mortality from non-communicable diseases. Thus, it is interesting to analyze and probe the relationship between tongue examination and CKD. This protocol is a cross-sectional, case-controlled observational study investigating the usefulness of the ATDS in clinical practice by examining its efficacy as a diagnostic tool for CKD. Volunteers over 20 years old with and without CKD will be enrolled. Tongue images will be captured and the patients divided into 2 groups: CKD group and healthy group. Nine primary tongue features will be extracted and analyzed, including tongue shape, tongue color, tooth mark, tongue fissure, fur color, fur thickness, saliva, ecchymosis, and red dots. The results of this study will systematically evaluate tongue manifestations of patients and examine its efficacy as an early detection and diagnosis of CKD. The aim of this protocol is to investigate discriminating tongue features to distinguish between CKD and normal people, and establish differentiating index to facilitate the noninvasive detection of CKD. ClinicalTrials.gov; Identifier: NCT04708743.