MMP-9 (Gelatinase B) Expression is Associated With Disease-Free Survival and Disease-Specific Survival in Colorectal Cancer Patients

ABSTRACT Extracellular matrix degradation is required for invasion and metastasis formation in colorectal carcinoma (CRC), therefore, we have examined matrix metalloproteinases MMP-9 expression in tumors from patients with CRC. The study comprises of 360 patients who underwent bowel resection for st...

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Bibliographic Details
Published inCancer investigation Vol. 28; no. 1; pp. 38 - 43
Main Authors Bendardaf, Riyad, Buhmeida, Abdelbaset, Hilska, Marja, Laato, Matti, Syrjänen, Stina, Syrjänen, Kari, Collan, Yrjö, Pyrhönen, Seppo
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 01.01.2010
Taylor & Francis
Subjects
Aged
Biomarkers, Tumor - analysis
Carcinoma - enzymology
Carcinoma - mortality
Carcinoma - secondary
Carcinoma - surgery
Clinico-pathological data
Colectomy
Colorectal carcinoma
Colorectal Neoplasms - enzymology
Colorectal Neoplasms - mortality
Colorectal Neoplasms - secondary
Colorectal Neoplasms - surgery
Disease-Free Survival
Female
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Male
Matrix Metalloproteinase 9 - analysis
Middle Aged
MMP-9
Neoplasm Recurrence, Local
Neoplasm Staging
Odds Ratio
Patients survival
Predictive Value of Tests
Proportional Hazards Models
Risk Assessment
Time Factors
Tissue Array Analysis
Treatment Outcome
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Summary:ABSTRACT Extracellular matrix degradation is required for invasion and metastasis formation in colorectal carcinoma (CRC), therefore, we have examined matrix metalloproteinases MMP-9 expression in tumors from patients with CRC. The study comprises of 360 patients who underwent bowel resection for stage II, III, IV tumors. Paraffin-embedded CRC tissue samples were used for immunohistochemical staining. Negative MMP-9 expression levels correlated with longer survival time as evaluated by disease-free survival and disease-specific survival (p =.023, p =.006). In multivariate survival (Cox) analysis, MMP9 was a significant independent predictor of DFS (p =.014), but not of DSS, which was independently predicted by disease recurrence, stage and localization. The detection of MMP-9 expression may be valuable in finding patients who are at high risk of developing disease recurrence.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0735-7907
1532-4192
DOI:10.3109/07357900802672761