The prevalence of osteoporosis and the rate of bone loss in Korean adults: the Chungju metabolic disease cohort (CMC) study

• Published in: Osteoporosis international Vol. 28; no. 4; pp. 1453 - 1459
• Main Authors: Lim, Y., Jo, K., Ha, H.-S., Yim, H.-W., Yoon, K.-H., Lee, W.-C., Son, H.-Y., Baek, K. H., Kang, M.-I.
• Format: Journal Article
• Language: English
• Published: London Springer London 01.04.2017; Springer Nature B.V
• Subjects: Adult; Age; Age Distribution; Aged; Aged, 80 and over; Aging - physiology; Bone Density - physiology; Bone Diseases, Metabolic - epidemiology; Bone Diseases, Metabolic - physiopathology; Bone loss; Bone mineral density; Cohort analysis; Cohort Studies; Endocrinology; Female; Females; Femur Neck - physiopathology; Fractures; Hip; Hip Joint - physiopathology; Humans; Longitudinal Studies; Lumbar Vertebrae - physiopathology; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Orthopedics; Osteoporosis; Osteoporosis - epidemiology; Osteoporosis - physiopathology; Prevalence; Republic of Korea - epidemiology; Rheumatology; Rural Health - statistics & numerical data; Spine; Osteoporosis; Bone mineral density; Bone loss; Cohort studies; Age-related
• ISSN: 0937-941X; 1433-2965; 1433-2965
• DOI: 10.1007/s00198-016-3893-z

Summary Because the rate of bone loss is an important risk factor for fracture, we studied longitudinal changes in bone mineral density (BMD). Although the BMD of the hip decreased over time, spine BMD remained largely stable or increased. Therefore, spine BMD may not be appropriate for assessing BMD change. Introduction The rate of age-dependent bone loss has been shown to be an important risk factor for fracture. However, longitudinal rates of BMD loss in Korea have not yet been reported. The objective of this study was to evaluate longitudinal changes in BMD in Korea. Methods This cohort study was performed in a population of individuals 40 years of age or older living in the rural area of Chungju City, Korea. A second BMD examination was conducted approximately 4 years after a baseline examination. A total of 3755 of the 6007 subjects completed the follow-up visit, corresponding to a follow-up rate of 62.51%. Results The age-standardized osteoporosis prevalence was 12.81% in males and 44.35% in females. In males, the average annual BMD loss at the total hip increased from −0.25% per year in their 40s to −1.12% per year in their 80s. In females, the average annual BMD loss at the total hip increased from −0.69% per year in their 40s to −1.51% per year in their 80s. However, the average annual percentage change in spine BMD in females increased from −0.91% per year in their 40s to +1.39% per year in their 80s. Conclusions A substantial number of subjects had osteoporosis, even though we standardized the prevalence of osteoporosis. In total hip, the mean BMD was decreased during the follow-up period; in addition, the annual percentage loss increased with age. However, spine BMD remained approximately stable or increased over time and therefore may not be appropriate for assessing BMD change.