End-season daily weight gains as rationale for targeted selective treatment against gastrointestinal nematodes in highly exposed first-grazing season cattle

• Published in: Preventive veterinary medicine Vol. 138; pp. 104 - 112
• Main Authors: Merlin, Aurélie, Chauvin, Alain, Lehebel, Anne, Brisseau, Nadine, Froger, Sébastien, Bareille, Nathalie, Chartier, Christophe
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2017; Elsevier
• Subjects: Animal Husbandry; Animals; Anthelmintics - therapeutic use; Antibodies, Helminth; Average daily weight gain; Cattle; Cattle Diseases - drug therapy; Cattle Diseases - parasitology; ELISA Ostertagia ODR; Feces - parasitology; France; Gastrointestinal Diseases - drug therapy; Gastrointestinal Diseases - parasitology; Gastrointestinal Diseases - veterinary; Grazing management practices; Heifer-Nematoda; Life Sciences; Linear Models; Nematoda; Ostertagia; Ostertagiasis - drug therapy; Ostertagiasis - veterinary; Parasite Egg Count; Refugia; Risk Assessment; ROC Curve; Targeted selective treatment; Weight Gain; BSS; FEC; Targeted selective treatment; ROC; Average daily weight gain; GMP; ILP; ADWG; GIN; FGSC; Refugia; Grazing management practices; FGS; TEC; TST; Heifer-Nematoda; ELISA Ostertagia ODR; DISCO; EXP; ODR
• ISSN: 0167-5877; 1873-1716
• DOI: 10.1016/j.prevetmed.2017.01.011

A two-year study was carried out to assess the feasibility of a targeted selective treatment to control gastrointestinal nematodes (GIN) in 24 groups of first grazing season (FGS) cattle. A two-step procedure aiming at defining exposure risk at group level and at identifying the most infected individuals within groups through measurement of the average daily weight gain (ADWG) at housing was used. The first step was to define retrospectively, by grazing management practices (GMP) indicators, two levels of groups’ exposure to GIN determined by anti O. ostertagi antibody ODR level (cut-off 0.7). For the low level of exposure, no relationship between parasitological parameters and heifer growth was seen, whereas for the high level ADWG was negatively correlated with increasing Ostertagia ODR values. The best classification was obtained with an expert system modelling the number of Ostertagia L3 generations on plots. GMP input for the expert system included standard data (turnout/housing data and supplementary feeding amount) combined with paddock rotation planning and monthly temperatures. The threshold of 3 successive generations of L3 or more on plots allowed identifying the groups according to low or high infection exposure level, except two groups that were misidentified as being highly exposed. In the second step, individual ADWG was found to be negatively associated with Ostertagia ODR in heifers from groups classified as highly exposed (≥3 generations of L3). In these groups, sensitivity and specificity of ADWG thresholds were calculated for several individual Ostertagia ODR thresholds. The best compromise between sensitivity (i.e., correctly treating the heifers that need to be treated) and specificity (i.e., not treating animals that should not be treated) was equivalent respectively to 76% and 56% (AUC≈0.7) and was reached using an end-season ADWG threshold of 683g/day to detect animals exhibiting an Ostertagia ODR cut-off at 0.93. Other ADWG thresholds were proposed taking into account the farmers’ or the veterinarians’ objectives: either maximizing the production through both an increase of the ADWG threshold and the sensitivity or keeping a significant nematode population in refugia with a corresponding limitation of anthelmintic treatments through a decrease of ADWG threshold and an increase of the specificity. Finally, a targeted selective treatment for FGS cattle based on GMP and flexible ADWG thresholds seems feasible at housing without laboratory analysis, accepting that some resilient animals with high Ostertagia ODR will not be treated due to their ability to perform under parasitic challenge.