Synthesis of 5-hydroxy- and 5-sulfanyl-substituted [1,2,3]triazolo[4,5-е][1,4]diazepines

5-Amino- N -(2,2-dimethoxyethyl)-1 Н -1,2,3-triazole-4-carboxamides in formic acid were subjected to intramolecular cyclization to 5-hydroxy[1,2,3]triazolo[4,5- е ][1,4]diazepines, which were converted by treatment with S-nucleophiles to 5-thio-functionalized derivatives.

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Bibliographic Details
Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 54; no. 8; pp. 789 - 795
Main Authors Kemskiy, Sergiy V., Syrota, Natalia A., Bol’but, Andriy V., Dorokhov, Viktor I., Vovk, Mykhaylo V.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2018
Springer Nature
Springer
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Formic acid
Nucleophiles
Organic acids
Organic Chemistry
Pharmacy
Physical Sciences
Science & Technology
(2,2-dimethoxyethyl)-1
1,2,3-triazole-4-carboxamides
intramolecular cyclization
thiofunctionalization
5-amino
[1,4]diazepines
1,2,3]triazolo[4,5
ANESTHESIA
ANALOGS
GUANASE
[1,2,3] triazolo[4,5-e][1,4] diazepines
AZEPINOMYCIN
INHIBITORS
5-amino-N-(2,2-dimethoxyethyl)-1H-1,2,3-triazole-4-carboxamides
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Summary:5-Amino- N -(2,2-dimethoxyethyl)-1 Н -1,2,3-triazole-4-carboxamides in formic acid were subjected to intramolecular cyclization to 5-hydroxy[1,2,3]triazolo[4,5- е ][1,4]diazepines, which were converted by treatment with S-nucleophiles to 5-thio-functionalized derivatives.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-018-2350-7