Hemodialysis Decreases Serum Brain-Derived Neurotrophic Factor Concentration in Humans

• Published in: Neurochemical research Vol. 37; no. 12; pp. 2715 - 2724
• Main Authors: Zoladz, Jerzy A., Śmigielski, Michał, Majerczak, Joanna, Nowak, Łukasz R., Zapart-Bukowska, Justyna, Smoleński, Olgierd, Kulpa, Jan, Duda, Krzysztof, Drzewińska, Joanna, Bartosz, Grzegorz
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.12.2012; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Antioxidants; Biochemistry; Biomedical and Life Sciences; Biomedicine; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - blood; Cell Biology; End-stage renal disease; F2-Isoprostanes - blood; Hemodialysis; Humans; Hydrocortisone; Hydrocortisone - blood; Isoprostanes; Kidney diseases; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - therapy; Male; Middle Aged; Neurochemistry; Neurology; Neurosciences; Original Paper; Oxidative Stress; Platelets; Renal Dialysis; Vitamin E; Kidney disease; Isoprostanes; Oxidative stress; Cortisol; BDNF; Ageing
• ISSN: 0364-3190; 1573-6903
• DOI: 10.1007/s11064-012-0862-6

In the present study we have evaluated the effect of a single hemodialysis session on the brain-derived neurotrophic factor levels in plasma [BDNF] pl and in serum [BDNF] s as well as on the plasma isoprostanes concentration [F 2 isoprostanes] pl , plasma total antioxidant capacity (TAC) and plasma cortisol levels in chronic kidney disease patients. Twenty male patients (age 69.8 ± 2.9 years (mean ± SE)) with end-stage renal disease undergoing maintenance hemodialysis on regular dialysis treatment for 15–71 months participated in this study. A single hemodialysis session, lasting 4.2 ± 0.1 h, resulted in a decrease ( P  = 0.014) in [BDNF] s by ~42 % (2,574 ± 322 vs. 1,492 ± 327 pg ml −1 ). This was accompanied by an increase ( P  < 10 −4 ) of [F 2 -Isoprostanes] pl (38 ± 3 vs. 116 ± 16 pg ml −1 ), decrease ( P  < 10 −4 ) in TAC (1,483 ± 41 vs. 983 ± 35 trolox equivalents, μmol l −1 ) and a decrease ( P  = 0.004) in plasma cortisol level (449.5 ± 101.2 vs. 315.3 ± 196.3 nmol l −1 ). No changes ( P  > 0.05) in [BDNF] pl and the platelets count were observed after a single dialysis session. Furthermore, basal [BDNF] s in the chronic kidney disease patients was significantly lower ( P  = 0.03) when compared to the age-matched control group ( n  = 23). We have concluded that the observed decrease in serum BDNF level after hemodialysis accompanied by elevated [F 2 -Isoprostanes] pl and decreased plasma TAC might be caused by enhanced oxidative stress induced by hemodialysis.