Specificities of the Skin Morphology in Juvenile Minipigs

• Published in: Toxicologic pathology Vol. 46; no. 7; p. 821
• Main Authors: Gauthier, Béatrice E, Penard, Laure, Bordier, Nicole F, Briffaux, Jean-Paul J, Ruty, Bernard M
• Format: Journal Article
• Language: English
• Published: United States 01.10.2018
• Subjects: Administration, Cutaneous; Aging - pathology; Animals; Drug Evaluation, Preclinical; Female; Male; Pharmaceutical Preparations - administration & dosage; Skin - anatomy & histology; Skin - drug effects; Skin - pathology; Swine; Swine, Miniature; Toxicity Tests; skin; juvenile; cartography; histology; minipig; miniature swine
• ISSN: 1533-1601
• DOI: 10.1177/0192623318804520

The Göttingen minipig is recognized by the scientific community and by health authorities as the animal model of choice to evaluate dermally applied drugs under development. Young adults of approximately 4 months of age are most generally chosen to participate in dermal pharmacology and toxicology studies, and recently, minipigs have been proved to be also suitable for juvenile studies. A complete anatomical cartography of the skin morphology of juvenile male and female minipigs from postnatal day 1 (PND1) to twelve weeks of age was performed measuring the thickness of skin layers for each anatomical location and time point. Overall, the neonatal skin of minipigs (PND1 and PND8) shows prominent cellularity, similar to that seen in human neonates, and the morphology of the skin of older animals is considered similar to that of young adult minipigs. Epidermal thickness varies only minimally over the period; whereas, the dermal and more markedly, the subcutaneous thicknesses increase over time.