Vanillin Attenuated Behavioural Impairments, Neurochemical Deficts, Oxidative Stress and Apoptosis Against Rotenone Induced Rat Model of Parkinson’s Disease

• Published in: Neurochemical research Vol. 41; no. 8; pp. 1899 - 1910
• Main Authors: Dhanalakshmi, Chinnasamy, Janakiraman, Udaiyappan, Manivasagam, Thamilarasan, Justin Thenmozhi, Arokiasamy, Essa, Musthafa Mohamed, Kalandar, Ameer, Khan, Mohammed Abdul Sattar, Guillemin, Gilles J.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2016; Springer Nature B.V
• Subjects: Animals; Antioxidants - pharmacology; Antioxidants - therapeutic use; Apoptosis - drug effects; Apoptosis - physiology; Benzaldehydes - pharmacology; Benzaldehydes - therapeutic use; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Dose-Response Relationship, Drug; Male; Maze Learning - drug effects; Maze Learning - physiology; Mental Disorders - chemically induced; Mental Disorders - drug therapy; Mental Disorders - metabolism; Neurochemistry; Neurology; Neurosciences; Original Paper; Oxidative Stress - drug effects; Oxidative Stress - physiology; Parkinsonian Disorders - chemically induced; Parkinsonian Disorders - drug therapy; Parkinsonian Disorders - metabolism; Rats; Rats, Wistar; Rotenone - toxicity; Oxidative stress, apoptosis; Vanillin; Parkinson’s disease; Motor and non-motor symptoms
• ISSN: 0364-3190; 1573-6903
• DOI: 10.1007/s11064-016-1901-5

Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling organic aromatic compound, is widely used as a flavoring additive in food, beverage, cosmetic and drug industries. It is reported to cross the blood brain barrier and also displayed antioxidant and neuroprotective activities. We previously reported the neuroprotective effect of vanillin against rotenone induced in in vitro model of PD. The present experiment was aimed to analyze the neuroprotective effect of vanillin on the motor and non-motor deficits, neurochemical variables, oxidative, anti-oxidative indices and the expression of apoptotic markers against rotenone induced rat model of Parkinson’s disease (PD). Rotenone treatment exhibited motor and non-motor impairments, neurochemical deficits, oxidative stress and apoptosis, whereas oral administration of vanillin attenuated the above-said indices. However further studies are needed to explore the mitochondrial protective and anti-inflammatory properties of vanillin, as these processes play a vital role in the cause and progression of PD.