Sulfur stereogenic centers in transition-metal-catalyzed asymmetric C-H functionalization: generation and utilization

Transition-metal-catalyzed enantioselective C-H functionalization has emerged as a powerful tool for the synthesis of enantioenriched compounds in chemical and pharmaceutical industries. Sulfur-based functionalities are ubiquitous in many of the biologically active compounds, medicinal agents, funct...

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Published inChemical science (Cambridge) Vol. 12; no. 33; pp. 1972 - 1984
Main Authors Liu, Wentan, Ke, Jie, He, Chuan
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 25.08.2021
The Royal Society of Chemistry
Subjects
Chemical compounds
Chemical synthesis
Chemistry
Enantiomers
Functional groups
Functional materials
Stereoselectivity
Sulfur
Transition metals
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Summary:Transition-metal-catalyzed enantioselective C-H functionalization has emerged as a powerful tool for the synthesis of enantioenriched compounds in chemical and pharmaceutical industries. Sulfur-based functionalities are ubiquitous in many of the biologically active compounds, medicinal agents, functional materials, chiral auxiliaries and ligands. This perspective highlights recent advances in sulfur functional group enabled transition-metal-catalyzed enantioselective C-H functionalization for the construction of sulfur stereogenic centers, as well as the utilization of chiral sulfoxides to realize stereoselective C-H functionalization. This perspective highlights sulfur functional groups enabled enantioselective C-H functionalization for the construction of sulfur stereogenic centers, and the utilization of chiral sulfoxide to realize stereoselective C-H functionalization.
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ISSN:2041-6520
2041-6539
DOI:10.1039/d1sc02614c