5,10-Methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) gene polymorphisms and adult meningioma risk
The causes of meningiomas are not well understood. Folate metabolism gene polymorphisms have been shown to be associated with various human cancers. It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase ( MTHF...
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Published in | Journal of neuro-oncology Vol. 115; no. 2; pp. 233 - 239 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Boston
Springer US
01.11.2013
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | The causes of meningiomas are not well understood. Folate metabolism gene polymorphisms have been shown to be associated with various human cancers. It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (
MTHFR
), methionine synthase (
MTRR
), and methionine synthase reductase (
MTR
) and risk of adult meningioma. A population-based case–control study involving 600 meningioma patients (World Health Organization [WHO] Grade I, 391 cases; WHO Grade II, 167 cases; WHO Grade III, 42 cases) and 600 controls was done for the
MTHFR
C677T and A1298C,
MTRR
A66G, and
MTR
A2756G variants in Chinese Han population. The folate metabolism gene polymorphisms were determined by using a polymerase chain reaction–restriction fragment length polymorphism assay. Meningioma cases had a significantly lower frequency of
MTHFR
677 TT genotype [odds ratio (OR) = 0.49, 95 % confidence interval (CI) 0.33–0.74;
P
= 0.001] and T allele (OR = 0.80, 95 % CI 0.67–0.95;
P
= 0.01) than controls. A significant association between risk of meningioma and
MTRR
66 GG (OR = 1.41, 95 % CI 1.02–1.96;
P
= 0.04) was also observed. When stratifying by the WHO grade of meningioma, no association was found. Our study suggested that
MTHFR
C677T and
MTRR
A66G variants may affect the risk of adult meningioma in Chinese Han population. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-News-1 ObjectType-Feature-3 |
ISSN: | 0167-594X 1573-7373 |
DOI: | 10.1007/s11060-013-1218-z |